top of page
Post-Infectious IBS Article Website Header-1200.png

The Untold Story of IBS: Post Infectious Irritable Bowel Syndrome

Irritable Bowel Syndrome (IBS) is one of the most common gastrointestinal conditions around the world, affecting an estimated 10-15% of both the global population and the population of the United States. Additionally, surveys show that many cases of IBS in the U.S. go undiagnosed, and up to two-thirds of Americans report living with IBS-like symptoms such as gas, bloating, constipation, and diarrhea. IBS is a really big deal, undermining the quality of life of millions of people of all ages and walks of life.

 

Because of its widespread impact, IBS has become the subject of an immense amount of scientific and medical research. Unfortunately, while this extensive study has resulted in some great advances in our understanding of the condition, the exact cause or causes of IBS are not always known.


However, new research reveals that in some cases there is a strong causative link between foodborne gastric infection (commonly called “food poisoning”) and IBS, resulting in what is termed Post-Infectious Irritable Bowel Syndrome or PI-IBS.

IBS-D & IBS-M

PieChart.jpg

>60%

<40%

Other sources

Post-infectious

More than 60% of IBS-D cases could
be post-infectious.

1 out of every 9 patients with food poisoning went on to develop IBS

AGA Logo.png

A review conducted by the Mayo Clinic and published in Gastroenterology, the official journal of the American Gastroenterology Association, found that 1 out of every 9 patients with food poisoning went on to develop IBS, and those who had contracted food poisoning were four times more likely to develop IBS than those who had not. Furthermore, in those patients diagnosed with more diarrhea-dominant IBS subtypes (IBS-D and IBS-M) up to 60% have been found with markers that indicate their IBS may be post-infectious in nature.

So, what exactly is going on inside your body in these cases? What symptoms and risk factors should you be looking for? And most importantly, can you test yourself for PI-IBS and possibly find the relief that you deserve? (Spoiler alert: the answer to this last question is YES!)

How Does Food Poisoning Lead to IBS?

At this point, you are probably curious about why food poisoning sometimes leads to IBS. After all, if your acute symptoms are gone or you aren’t entirely sure you ever even had food poisoning, how could it be leading you to now be experiencing this chronic, often seriously debilitating condition? Let’s take a look inside your body and see what’s going on.

Though a variety of microorganisms and factors can lead to foodborne illnesses, it is most commonly caused by bacteria. You’ve probably heard of many of the main culprits before: Salmonella, Escherichia coli (E. coli), Clostridium, Shigella, and Campylobacter. These types of bacteria thrive in our foods naturally but can become present at dangerous levels when our food is not properly stored, prepared, or cooked.

Dr. Mark Pimentel explains CdtB and its function in food poisoning.

Bacteria like these can release a toxin into your body called Cytolethal Distending Toxin B or CdtB. When your body identifies that CdtB is present, your immune system goes to work, fighting back with an antibody aimed at eliminating the toxin. This antibody is aptly named anti-CdtB. This is a typical type of immune response and your body is doing what it is designed to do, which is generally a good thing!

Unfortunately, CdtB also looks in some ways like something called vinculin, a naturally occurring protein in your body that helps to regulate gut motility (keeping food in your gut moving in a regular fashion) and is critical for healthy gut function. And because CdtB and vinculin can look alike, your body may mistakenly think it also needs to fight back against vinculin, too. So, it produces another antibody called anti-vinculin.

Dr. Pimentel explains how CdtB and Vinculin can lead to PI-IBS.

The production of anti-vinculin is an autoimmune response with unintended consequences. Increased levels of anti-vinculin have been shown to damage gut nerves, decrease the density of your Interstitial Cells of Cajal (ICC), and impair the functioning of your Migrating Motor Complexes (MMC). All of these result in dysregulation of your gut’s normal cycles that move contents through your digestive tract at a healthy, rhythmic pace, which can lead to significant imbalances in your gut’s microbiome.

Here's an illustration of how an instance of food poisoning develops into post-infectious IBS.

How food poisoning turnsing into IBS

Imbalances of this nature can ultimately result in PI-IBS and the abdominal distress that comes with it, which most often presents as diarrhea-predominant IBS (IBS-D) or IBS characterized by a mixture of diarrhea and constipation (IBS-M). Your bout with food poisoning therefore results in a biological case of mistaken identity that can have serious, long-lasting implications on your health and quality of life.

Could I Have PI-IBS?

Anyone with an IBS diagnosis or who has been experiencing IBS symptoms is potentially at risk, but you are more likely to have post-infectious IBS if:

 

  • You have received a specific diagnosis of IBS-D (IBS with diarrhea-predominant symptoms) or IBS-M (IBS with mixed symptoms with diarrhea as one component)

  • You experience chronic diarrhea, traveler’s diarrhea, or a mixture of diarrhea and constipation on an ongoing basis

  • You have abdominal pain and bloating

  • You have a sensation of incomplete emptying after bowel movements

  • You have no other serious symptoms (such as blood in your stool)

  • It’s possible you’ve had a foodborne illness (food poisoning) in the past

 

One of the most difficult aspects of knowing whether you may be at risk for PI-IBS is that foodborne illness is not always diagnosed or properly attributed. The Centers for Disease Control (CDC) estimates that “each year roughly 1 in 6 Americans (or 48 million people) gets sick, 128,000 are hospitalized, and 3,000 die of foodborne diseases.” This is a huge number! But only a small percentage of these cases are ever officially diagnosed and treated since the acute symptoms of food poisoning often resolve themselves without specific medical intervention.

 

Unfortunately, that means there could be unexpected long-term consequences of contracting these foodborne illnesses. And since there is sometimes a lag between contracting a foodborne illness and the onset of PI-IBS, it’s not always easy or possible to make the correlation. “You may not recall a history of food poisoning, and you may not remember a few days of diarrhea,” writes renowned gut-health expert Dr. Mark Pimentel in The Microbiome Connection. “In fact, your IBS symptoms may have begun several months after the initial food poisoning.”

 

For this reason, it’s important to take into account the other symptoms and risk factors–especially the presence of diarrhea–which research suggests is the most common indication of PI-IBS.

Can I Be Tested for PI-IBS?

Since we now know how foodborne illness can lead to PI-IBS and we understand the underlying biological mechanisms at work within our bodies, the next logical question is, “Can we test for PI-IBS?” Fortunately, with the IBS-Smart test from Gemelli Biotech, the answer is YES.

 

Here’s how it works:

 

IBS-Smart measures the levels of the two antibodies we discussed previously that are known to be elevated in patients with PI-IBS: antiCdtB and anti-vinculin. This is accomplished by collecting a small sample of blood from your arm, which can be done from the comfort of your own home with an easy-to-use blood collection device. This sample is then sent back to Gemelli Biotech’s lab for evaluation. The levels of each antibody are compared to known normal values, and any values that exceed thresholds that are indicative of patients with PI-IBS are flagged for review.

About a week after you send your sample back, you will receive your results including actual antibody numbers and any values that are flagged. With this information in hand, you can discuss your findings with your healthcare provider and take appropriate action to manage or treat your condition.

​

IBS-Smart, developed by Dr. Mark Pimentel and the Medically Associated Science and Technology (MAST) Program at Cedars-Sinai in Los Angeles, California, is the only licensed antibody blood test that can positively identify Post-Infectious IBS. It has been scientifically validated to identify patients with PI-IBS with a positive predictive value of 96-100%.

Tasso device on man

So, when you receive your results, you will have the confidence of knowing whether or not your IBS or IBS symptoms are due to PI-IBS.

Why Does It Matter?

On your gut health journey, it is critical to obtain as much information as possible about what you are experiencing and what’s going on inside your gut. This will allow you and your healthcare providers the ability to develop a comprehensive plan that best addresses your condition or conditions. There are treatments and symptom management options available that are specifically tailored for patients with PI-IBS, including certain antibiotics and diet modifications.

 

So, knowing whether or not your IBS or IBS-like symptoms are post-infectious could put you on a path to faster, more effective treatment. It may also save you a significant amount of time and money that would otherwise be spent on potentially unnecessary office visits and procedures. Your health is your most important asset, and you deserve to find answers… and relief.

Order IBS-Smart Online.

No appointment necessary

You can work with a doctor online to order IBS-Smart, if it’s right for you.

The online prescriber service includes: 

​

  • A symptom evaluation by a doctor

  • Clear and actionable results emailed directly to you

IBS-Smart Animated Video
Play Video

Prefer to work with your healthcare provider instead? Download the IBS-Smart discussion guide and educational materials here

Woman%20Purple%20Lights%20SIBO%202_edite

SIBO & IBS

While what causes SIBO is an excess of bacteria, there are many conditions that can lead to SIBO like irritable bowel syndrome.

Diarrhea_Purplish.jpg

Diarrhea & IBS

Chronic diarrhea can indicate disorders, such as inflammatory bowel disease (IBD) or irritable bowel syndrome (IBS).

IBS%20Image%205_edited.jpg

​

IBD vs. IBS

While irritable bowel syndrome and inflammatory bowel disease share some symptoms, they are completely different illnesses. 

bottom of page